TOTAL ANTIOXIDANT CAPACITY AND ANTIHYPERLIPIDEMIC ACTIVITY OF ALKALOID EXTRACT FROM AERIAL PART OF ANETHUM GRAVEOLENS L. PLANT

  • Adnan J.M. Al–Fartosy Chemistry Department, College of Science, Basra University, Iraq
  • Sameerah Ahmed Zearah Chemistry Department, College of Science, Basra University, Iraq
  • Nawras A. Alwan Physiological and Chemistry Department, College of Veterinary Medicine, Basra University, Iraq

Abstract

Compounds of pharmacological interest (alkaloids) were extracted and the results revealed that the extract consist of three alkaloid compounds (A, B & C). Compound (A) has been isolated from Anethum graveolens L. aerial parts by column chromatography using C6H6 : Ethanol (9:1) solvent as eluent. It was found that simultaneous administration of alkaloid compound A (500 mg/kg/day) and cholesterol for 4 weeks, significantly (P<0.01) prevented the rise in serum TC, TG, LDL-cholesterol, VLDL-cholesterol, atherogenic index and significantly (P<0.01) increased TAC and HDL-cholesterol as compared to cholesterol fed control rabbits. Thus, the results indicate antioxidant and hypolipidemic effect of alkaloid compound A of Anethum graveolens L. aerial parts.

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Published
2013-11-30
How to Cite
Al–Fartosy, A. J., Zearah, S. A., & Alwan, N. A. (2013). TOTAL ANTIOXIDANT CAPACITY AND ANTIHYPERLIPIDEMIC ACTIVITY OF ALKALOID EXTRACT FROM AERIAL PART OF ANETHUM GRAVEOLENS L. PLANT. European Scientific Journal, ESJ, 9(33). https://doi.org/10.19044/esj.2013.v9n33p%p